Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice |
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| Authors: | Takashi Imai Takao Iwawaki Ryoko Akai Kazutomo Suzue Makoto Hirai Tomoyo Taniguchi Hiroko Okada Hajime Hisaeda |
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| Institution: | 1. Department of Parasitology, Graduate School of Medicine, Gunma University, Gunma 371-8511, Japan;2. Iwawaki Laboratory, Advanced Scientific Research Leaders Development Unit, Gunma University, Gunma 371-8511, Japan;3. Center for Medical Education, Faculty of Medicine, Gunma University, Gunma 371-8511, Japan |
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| Abstract: | Cerebral malaria is a fatal complication of malaria. Conventional methods for evaluating experimental cerebral malaria have several drawbacks. Therefore, we aimed to develop an easy-to-use method for evaluating experimental cerebral malaria using OKD48 (Keap1-dependent Oxidative stress Detector, No-48-luciferase) mice to evaluate oxidative stress. OKD48 mice infected with Plasmodium berghei ANKA strain (PbA) suffered from experimental cerebral malaria and oxidative stress was successfully detected in the brains of living OKD48 mice developing experimental cerebral malaria. Oxidative stress in the brain was dependent on the development of experimental cerebral malaria, as prevention of experimental cerebral malaria did not elicit oxidative stress. We provide a novel evaluation method for experimental cerebral malaria using oxidative stress indicator OKD48 mice. |
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| Keywords: | Malaria Experimental cerebral malaria Oxidative stress In vivo imaging |
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