三拗片联合布地奈德混悬液雾化吸入对急性支气管炎患儿炎症细胞因子和T淋巴细胞亚群的影响

摘要 目的：观察布地奈德混悬液雾化吸入、三拗片联合治疗对急性支气管炎患儿T淋巴细胞亚群、炎症细胞因子的影响。方法：选取2021年1月到2023年1月期间合肥市第二人民医院收治的急性支气管炎患儿78例，按照双色球法将患儿分为对照组和研究组，各为39例。对照组患儿接受布地奈德混悬液雾化吸入，研究组患儿接受三拗片联合布地奈德混悬液雾化吸入。对比两组疗效、炎症因子水平、临床指标、T淋巴细胞亚群和用药安全性。结果：研究组的临床总有效率高于对照组（P<0.05）。研究组的喘息缓解时间、咳嗽缓解时间、体温正常缓解时间、肺部啰音缓解时间短于对照组（P<0.05）。治疗7 d后，两组降钙素原（PCT）、白细胞介素-8（IL-8）、白细胞介素-6（IL-6）下降，且研究组低于对照组（P<0.05）。治疗7 d后，两组CD8⁺下降，且研究组低于对照组（P<0.05）；两组CD4⁺、CD4⁺/CD8⁺升高，且研究组高于对照组（P<0.05）。两组患儿不良反应对比未见统计学差异（P>0.05）。结论：急性支气管炎患儿采用布地奈德混悬液雾化吸入联合三拗片治疗，有助于缩短临床症状缓解时间，减轻炎症细胞因子水平，调节T淋巴细胞亚群。

Effect of San'ao Tablets Combined with Budesonide Suspension Atomization Inhalation on Inflammatory Cytokines and T Lymphocyte Subsets in Children with Acute Bronchitis

ABSTRACT Objective: To observe the effect of atomized inhalation of Budesonide suspension and combined treatment of San''ao tablet on T lymphocyte subsets and inflammatory cytokines in children with Acute bronchitis. Methods: 78 children with acute bronchitis who were admitted to the Hefei Second People''s Hospital from January 2021 to January 2023 were selected, and the children were divided into control group and study group according to the dichroism method, 39 cases each. The children in control group received Budesonide suspension atomization inhalation, and the children in study group received San''ao tablets combined with Budesonide suspension atomization inhalation. The efficacy, inflammatory factor levels, clinical indicators, T lymphocyte subsets and medication safety between the two groups were compared between two groups. Results: The clinical total effective rate in study group was higher than that in control group (P<0.05). The study group had shorter relief times for wheezing, coughing, normal body temperature, and lung rales compared to the control group (P<0.05). 7 d after treatment, the procalcitonin (PCT), interleukin-8 (IL-8) and interleukin-6 (IL-6) decreased in two groups, and study group were lower than those in control group (P<0.05). 7 d after treatment, the CD8⁺ decreased in two groups, and study group was lower than that in control group (P<0.05). The CD4⁺ and CD4⁺/CD8⁺ increased in two groups, and study group were higher than those in control group (P<0.05). There was no statistically significant difference in adverse reactions in children between two groups (P>0.05). Conclusion: The treatment of children with Acute bronchitis by atomization inhalation of Budesonide suspension combined with San''ao tablet is helpful to shorten the time of clinical symptom relief, reduce the level of inflammatory cytokines and regulate T lymphocyte subsets.