West Nile virus core protein; tetramer structure and ribbon formation |
| |
Authors: | Dokland Terje Walsh Martin Mackenzie Jason M Khromykh Alexander A Ee Kim-Huey Wang Sifang |
| |
Affiliation: | Institute of Molecular and Cell Biology, Singapore, Republic of Singapore. dokland@uab.edu |
| |
Abstract: | We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |