Sister chromatid exchanges in the human active and inactive X chromosomes |
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| Authors: | A Zhang M S Lin M G Wilson A Fujimoto |
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| Institution: | Department of Pediatrics, Los Angeles County-University of Southern California Medical Center. |
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| Abstract: | Four human female fibroblast strains with an i(Xq) or derivative X chromosome as a cytological marker for the inactive X chromosome were used to determine the frequency of sister chromatid exchanges (SCEs) in the active and inactive X chromosomes. No significant difference in SCE frequency between the active and inactive X chromosomes was observed. Therefore, the state of chromatin condensation and the late DNA replication in the facultative heterochromatin of the inactive X chromosome do not appear to influence the SCE frequency. |
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