Complete cDNA sequence of bovine alpha 1-antitrypsin. |
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Authors: | D Sinha M R Bakhshi E P Kirby |
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Affiliation: | Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140. |
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Abstract: | A cDNA clone coding for the entire bovine alpha 1-antitrypsin molecule has been isolated from a lambda gt11 bovine liver cDNA library using a human alpha 1-antitrypsin cDNA as a probe. The bovine cDNA was sequenced by the dideoxynucleotide chain termination method. Comparison of the translated amino acid sequence of the bovine alpha 1-antitrypsin with those of the human, baboon, sheep, rat and mouse demonstrates the preservation of most of the critical structural determinants. The bovine and the sheep molecules have a sequence homology of 94% and both the molecules contain four cysteine residues; there is only one cysteine in the others. |
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