Protein folding diseases and neurodegeneration: lessons learned from yeast |
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Authors: | Winderickx Joris Delay Charlotte De Vos Ann Klinger Harald Pellens Klaartje Vanhelmont Thomas Van Leuven Fred Zabrocki Piotr |
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Institution: | Functional Biology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, Leuven-Heverlee, Belgium. joris.winderickx@bio.kuleuven.be |
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Abstract: | Budding yeast Saccharomyces cerevisiae has proven to be a valuable model organism for studying fundamental cellular processes across the eukaryotic kingdom including man. In this respect, complementation assays, in which the yeast protein is replaced by a homologous protein from another organism, have been very instructive. A newer trend is to use the yeast cell factory as a toolbox to understand cellular processes controlled by proteins for which the yeast lacks functional counterparts. An increasing number of studies have indicated that S. cerevisiae is a suitable model system to decipher molecular mechanisms involved in a variety of neurodegenerative disorders caused by aberrant protein folding. Here we review the current knowledge gained by the use of so-called humanized yeasts in the field of Huntington's, Parkinson's and Alzheimer's diseases. |
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