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Antiparasitic Activity of Auranofin against Pathogenic Naegleria fowleri
Authors:Nathan Peroutka‐Bigus  Bryan H Bellaire
Abstract:We report that the gold containing antirheumatoid drug auranofin is amoebicidal against human pathogenic Naegleria fowleri. Treatment of N. fowleri cultures at biologically relevant concentrations of 0.75–3.0 μg/ml auranofin reduced amoeba counts, metabolic activity, and increased cell permeability. These results suggest that the addition of auranofin may benefit the treatment of N. fowleri‐infected patients afflicted by the rapidly fatal disease primary amoebic meningoencephalitis.
Keywords:Amoeba  antimicrobial  in   vitro  primary amoebic meningoencephalitis
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