D-galactosamine induced changes in rat liver plasma membranes lipid composition and some enzyme activities |
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| Authors: | D H Petkova A B Momchilova T T Markovska K S Koumanov |
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| Institution: | Central Laboratory of Biophysics, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria |
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| Abstract: | The influence of D-galactosamine administration on rat liver plasma membranes lipid composition, fluidity and some enzyme activities was investigated. D-Galactosamine was found to induce an increase of the total phospholipids, the cholesterol level and membrane rigidity. In liver plasma membranes of D-galactosamine-treated rats the exogenous phospholipase A2 activity was enhanced about 2 fold, whereas the endogenous activity was slightly decreased. No alteration of the neutral sphingomyelinase activity was observed. |
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