Three-dimensional reconstruction of cell nuclei, internalized quantum dots and sites of lipid peroxidation |
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| Authors: | W Robert J Funnell Dusica Maysinger |
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| Affiliation: | 1. Departments of BioMedical Engineering and Otolaryngology, McGill University, 3775 rue University, Montréal, QC, H3A 2B4, Canada
2. Department of Pharmacology & Therapeutics, McGill University, 3655 promenade Sir-William-Osler, Montréal, QC, H3G 1Y6, Canada
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| Abstract: | Background The purpose of the study was to develop and illustrate three-dimensional (3-D) reconstruction of nuclei and intracellular lipid peroxidation in cells exposed to oxidative stress induced by quantum dots. Programmed cell death is characterized by multiple biochemical and morphological changes in different organelles, including nuclei, mitochondria and lysosomes. It is the dynamics of the spatio-temporal changes in the signalling and morphological adaptations which will ultimately determine the 'shape' and fate of the cell. |
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