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Understanding the computational methodologies of systems biology
Authors:Dubitzky Werner
Affiliation:University of Ulster
Northern Ireland
Abstract:The conventional approach to understanding biological systemsand processes employs a largely static view of loosely coupledmolecular and cellular elements. This contrasts with the basicunderstanding of a biologist that life is an inherently dynamicphenomenon. Similar to many other ontological concepts, a precisedefinition of systems biology may not be attainable for a longtime [1]. However, there seems to be a consensus that systemsbiology will progressively complement the conventional modeof study by facilitating the understanding of biological networksand mechanisms in terms of their dynamic system behavior ondifferent levels of organization. This new way of investigatingliving matter involves a tight coupling of mathematical modeling,computational analysis and simulation and biological experimentation. One
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