Induction of temporary sterility in female hamsters by an intraperitoneal Silastic-PVP-PGF2α tube |
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| Authors: | IF Lau SK Saksena MC Chang |
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| Institution: | Worcester Foundation for Experimental Biology Shrewsbury, Massachusetts 01545 USA |
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| Abstract: | In the female hamster, temporary sterility for a period of 10 or 15 days was induced by an intraperitoneal Silastic-PVP-tube containing 0.5 or 1.0 mg of PGF2α, respectively. All Silastic-PVP-PGF2α tube bearing animals regained fertility and delivered normal litters at various times after the placement of the tube. The release rate of 3H-PGF2α from the Silastic-PVP tube was described and their potential use as a drug delivery system discussed. |
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