Synthesis of -4,5,6-trinor-3,7-inter--phenylene-3-oxaprostaglandins including one which inhibits platelet aggregation |
| |
Authors: | Norman A Nelson RW Jackson AT Au DJ Wynalda EE Nishizawa |
| |
Institution: | Research Laboratories, The Upjohn Company, Kalamazoo, Michigan 49001 USA |
| |
Abstract: | The synthesis of -4,5,6-trinor-3,7-inter--phenylene-3-oxaprostaglandins oxaprostaglandins of the E1 and F1α series7 from 6-endo-(1-heptenyl)-bicyclo3:1:0]hexan-3-one (III), is described. Preliminary biological screening data for gerbil colon smooth muscle stimulation, rat blood pressure and substrate specificity toward 15-hydroxyprostaglandin dehydrogenase is presented. Platelet function studies, both and of -4,5,6-trinor-3,7-inter--phenylene-3-oxa-PGE1, methyl ester (VIII) are presented. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|