Butyric acid,a potent inducer of erythroid differentiation in cultured erythroleukemic cells |
| |
| Authors: | Aya Leder Philip Leder |
| |
| Institution: | 1. Laboratory of Molecular Genetics National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland 20014 USA;2. Department of Biological Chemistry The Hebrew University of Jerusalem Jerusalem, Israel |
| |
| Abstract: | Butyric acid is an unusually potent inducer of erythroid differentiation in cultured erythroleukemic cells. It is effective at one hundredth the concentration required of dimethylsulfoxide, a most effective inducing agent. Studies using a variety of analogues and metabolites suggest that the structural features of butyric acid are rather stringently required for induction. This effect is considered in view of the fact that butyric acid is a naturally occurring fatty acid, is effective in relatively low concentrations, and is widely used to form derivatives of cAMP. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
