Update on the proteomics of major arthropod vectors of human and animal pathogens |
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Authors: | Sirilaksana Patramool Valérie Choumet Pornapat Surasombatpattana Laurence Sabatier Frédéric Thomas Supatra Thongrungkiat Thierry Rabilloud Nathalie Boulanger David G Biron Dorothée Missé |
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Institution: | 1. Laboratoire MIVEGEC, UMR CNRS 5290/IRD 224/UM1, , Montpellier, France;2. Unité de Génétique Moléculaire des Bunyavirus, Institut Pasteur, , Paris, France;3. Département des Sciences Analytiques Institut Pluridisciplinaire Hubert Curien, , Strasbourg, France;4. Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, , Bangkok, Thailand;5. CNRS UMR 5249, Chemistry and Biology of Metals, CEA, , Grenoble, France;6. EA4438 Physiopathologie et médecine translationnelle, Faculté de Pharmacie, , Illkirch, France;7. CNRS UMR 6023, Laboratoire Microorganismes: Génome et Environnement, , Aubière, France |
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Abstract: | Vector‐borne diseases (VBDs) are defined as infectious diseases of humans and animals caused by pathogenic agents such as viruses, protists, bacteria, and helminths transmitted by the bite of blood‐feeding arthropod (BFA) vectors. VBDs represent a major public health threat in endemic areas, generally subtropical zones, and many are considered to be neglected diseases. Genome sequencing of some arthropod vectors as well as modern proteomic and genomic technologies are expanding our knowledge of arthropod–pathogen interactions. This review describes the proteomic approaches that have been used to investigate diverse biological questions about arthropod vectors, including the interplay between vectors and pathogens. Proteomic studies have identified proteins and biochemical pathways that may be involved in molecular crosstalk in BFA‐pathogen associations. Future work can build upon this promising start and functional analyses coupled with interactome bioassays will be carried out to investigate the role of candidate peptides and proteins in BFA‐human pathogen associations. Dissection of the host–pathogen interactome will be key to understanding the strategies and biochemical pathways used by BFAs to cope with pathogens. |
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Keywords: | Host– pathogen interaction Microbiology Midgut Saliva Vector‐borne diseases |
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