Effect of hydrocortisone and dexamethasone on xylose uptake by isolated rat soleus muscle |
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Authors: | Irshad H Chaudry N Scott Adzick Mohammed M Sayeed Arthur E Baue |
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Institution: | Waldheim Department of Surgery, Washington University School of Medicine and The Jewish Hospital of St. Louis, 216 S. Kingshighway, St. Louis, Mo. 63110, U.S.A. |
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Abstract: | To determine the effects of glucocorticoids on sugar uptake, xylose uptake by isolated rat soleus muscle of bilaterally adrenalectomized animals was studied. The results indicate that in vitro addition of 10?4 M hydrocortusine, dexamethasone or hydrocortisone sodium succinate had no inhibitory effect on basal xylose uptake. In the presence of both low and high medium insulin, the above steroids failed to inhibit insulin-stimulated uptake. When the concentration of hydrocortisone sodium succinate was increased to 10?2 M, insulin-stimulated uptake was decreased. The results thus indicate that glucocorticoids at concentrations observed under physiological or pathological conditions do not inihibit basal or insulin-stimulated sugar uptake. |
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