Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives |
| |
| Authors: | K Nesměrák H Pelouchová V V?ete?ka I Němec J Gabriel |
| |
| Institution: | (1) Faculty of Science, Charles University, 128 43 Prague 2, Czech Republic;(2) Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic |
| |
| Abstract: | Minimal inhibitory concentrations for 10 new condensed isoindole derivatives were established by the agar diffusion method.
Benzob]-6H-pyrimido2,1-a]isoindole-4-one exhibited a broad antifungal effect; the observed MIC (mg/L) were 7 (K. lactis), 8 (C. pseudotropicalis), 17 (W. fluorescens), 22 (E. magnusii), 31 (P. membranaefaciens), 32 (S. alluvius) and 32 (S. cerevisiae). The compound also inhibited the growth ofB. subtilis (MIC 9 mg/L). No effect on the growth ofE. coli was found. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
