| 抗白念珠菌生物被膜药物的研究进展 |
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| 引用本文： | 赵兰雪,李德东,王彦,姜远英. 抗白念珠菌生物被膜药物的研究进展[J]. 中国真菌学杂志, 2013, 8(2): 124-128 |
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| 作者姓名： | 赵兰雪 李德东 王彦 姜远英 |
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| 作者单位： | 1. 福建中医药大学药学院中药学教研室,福州350108;第二军医大学药学院新药研究中心,上海200433
2. 第二军医大学药学院新药研究中心,上海,200433 |
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| 基金项目： | 国家自然科学基金(项目编号：81072678,81273558,30825041)国家重点基础研究发展计划(项目编号：2013CB531602)上海市教育发展基金会晨光计划(项目编号：2007CG51) |
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| 摘 要： | 白念珠菌是临床最常见的一种能产生生物被膜的致病真菌,所产生的生物被膜是导致高度耐药性和临床白念珠菌反复感染的直接原因.近年来,科学家们开始关注天然产物的抗生物被膜活性,以及不同药物联合应用的抗生物被膜效果,该文对抗白念珠菌生物被膜药物的研究进展作一综述.
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| 关 键 词： | 生物被膜 白念珠菌 抗真菌药物 |
An update of antifungals functioning on inhibiting Candida albicans biofilm formation |
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| ZHAO Lan-xue , LI De-dong , WANG Yan , JIANG Yuan-ying. An update of antifungals functioning on inhibiting Candida albicans biofilm formation[J]. Chinese JOurnal of Mycology, 2013, 8(2): 124-128 |
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| Authors: | ZHAO Lan-xue LI De-dong WANG Yan JIANG Yuan-ying |
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| Affiliation: | 1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;2. New Drug Research and Development Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Candida albicans is the most common fungal pathogen which can form biofilm, and the formation of biofilm leads to drug resistance and repeated infections in clinic. Over recent years we have witnessed the discovery of natural products with anti-biofilm activity and the development of combination-therapy against Candida biofilm. The antifungal agents with anti-biofilm activity were discussed in this review. |
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| Keywords: | Candida albicans biofilm antifungal |
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