光动力治疗女性尖锐湿疣合并外阴阴道念珠菌病的临床疗效观察

目的评价5-氨基酮戊酸光动力治疗尖锐湿疣合并外阴阴道念珠菌病的临床疗效。方法治疗组66例患者采用光动力联合氟康唑胶囊和克霉唑栓,对照组50例患者采用冷冻联合氟康唑胶囊和克霉唑栓。结果治疗组尖锐湿疣完全反应率92.4%,对照组尖锐湿疣完全反应率78.0%,差异有统计学意义(χ2=4.978,P=0.026)。治疗组真菌感染治愈率97.0%,对照组真菌感染治愈率86.0%,差异有统计学意义(χ2=4.783,P=0.029)。随访6个月,治疗组尖锐湿疣复发率7.5%,对照组复发率24.0%,两组间差异有统计学意义(χ2=6.136,P=0.013)。随访2个月后复查真菌,治疗组真菌复发率4.5%,对照组复发率16.0%,治疗组复发率显著低于对照组,差异有统计学意义(χ2=4.349,P=0.037)。结论5-氨基酮戊酸光动力联合抗真菌治疗尖锐湿疣合并外阴阴道念珠菌病的患者安全、有效、复发率低。

Analysis of the efficacy of photodynamic therapy of condyloma acuminatum with vulvovaginal candidiasis of women infections

Objective To evaluate the clinical effect of 5-ALA photodynamic therapy in treating patient of condyloma acuminatum （CA） with vulvovaginal candidiasis infections.Methods The 66 cases in treatment group were treated by photodynamic combined with antifungal therapy, while the 50 cases in control group by frozen combined with antifungal therapy.Results Complete response rate of treatment group was 92.4%, while that of control group was 78.0%. The difference was statistically significant （χ2=4.978, P=0.026）; The cure rate of fungal infection of treatment group was 97.0%, while that of control group 86.0%. The difference was statistically significant （χ2=4.783, P=0.029）. Patients were followed up for 6 months, the recurrence rate of condyloma of treatment group was 7.5%, the control group 24.0% （χ2=6.136, P=0.013）. After 2 months of follow-up, the recurrence rate of fungi infection of treatment group was 4.5%, whlie the control group 16.0% （χ2=4.349, P=0.037）.Conclusion 5-ALA photodynamic combined with antifungal is a safe and effective treatment of condyloma acuminatum （CA） with vulvovaginal candidiasis with low recurrence rate.