帕金森病患者血浆alpha-synuclein、Abeta及tau蛋白变化特点

目的：探索帕金森病（Parkinson''s disease，PD）患者血浆中alpha- 突触核蛋白、Abeta及tau 蛋白变化情况。方法：募集2014 年4 月至2015 年4 月来我院就诊的PD 患者62 例，正常对照人群59 例，采集两组人群的基本临床信息，测定血浆中琢- 突触核蛋白、Abeta40、Abeta42、pT181-tau 蛋白、pT231-tau 蛋白和总tau 蛋白浓度，比较两组之间的差异，同时进行相关性分析。结果：PD患者血浆alpha- 突触核蛋白和pT181-tau 蛋白浓度显著高于对照组(P 值分别为0.001，0.019)，而两组间Abeta40、Abeta42、pT231-tau 蛋白和总tau蛋白浓度无明显差异（P>0.05）。相关性分析提示PD 患者血浆alpha-突触核蛋白和pT181-tau 蛋白浓度与患者年龄、性别、教育程度、病程、高血压、糖尿病、Hoehn/ Yahr 分级及Schwab &England 评分无相关性（P>0.05）。结论：虽然PD患者血浆琢- 突触核蛋白和pT181-tau 蛋白高于正常对照组，但尚不适宜作为PD 的生物标志物。

Characteristics of alpha-synuclein, Amyloid-beta and Tau Proteins in the Plasma ofPatients with Parkinson's Disease

Objective:To investigate the changes in the levels of alpha-synuclein, amyloid-beta(Abeta) and tau proteins in the plasma ofpatients with Parkinson''s disease.Methods:The study was carried out on patients with Parkinson''s disease (PD) and normal controls(NC). Participants with PD (n=59), NC (n=62) were consecutively recruited during a 1-year period fromApril 2014 to April 2015 fromDaping Hospital, and the clinical data were collected. The concentrations of aloha-synuclein, amyloid-beta and tau proteins in the plasma of PDand NC groups were measured and compared between two groups. Moreover, correlation analysis was also performed.Results:Theconcentrations of alpha-synuclein and tau phosphorylated at threonine 181 (pT181-tau) in the PD group were significantly higher than thosein the NC group (P=0.001, 0.019, respectively). There were no significance differences in the concentrations of Abeta40, Abeta42, pT231-tauand total-tau between two groups (P>0.05). Correlation analysis indicated that alpha-synuclein and pT181-tau did not correlated with age,gender, education, disease duration, hypertension, diabetes, Hoehn and Yahr stage and Schwab& England score (P>0.05).Conclusion:Although the plasma levels of alpha-synuclein and pT181-tau were found to be increased in PD patients, they seem not be capable of beingbiomarkers for PD.