乌司他丁对62例食管癌患者术后应激和炎症反应的影响

目的：观察乌司他丁对食管癌患者术后应激和炎症反应的影响。方法：选择我院2014年1 月至2015 年3 月接受手术治疗的食管癌患者124 例，随机分为两组，每组62 例。观察组术后给予乌司他丁治疗，对照组仅接受常规抗感染治疗。观察并比较两组患者手术后应激反应和炎性因子的变化情况。结果：术后3d 两组NE、E、Cor、TNF-alpha、IL-6、IL-8 水平均较术前明显升高（P＜0.05）。对照组NE、E、Cor、TNF-alpha、IL-6、IL-8水平升高幅度明显大于观察组，两组比较差异具有统计学意义（P＜0.05）。观察组并发症发生率为8.06%，对照组并发症发生率为19.35%，两组并发症发生率比较差异具有统计学意义（P＜0.05）。结论：食管癌患者行开胸切除术可引起全身炎症反应，乌司他丁的应用可抑制术后炎症因子的释放，减轻术后应激，对降低并发症的发生率，促进康复具有积极的作用。

Effect of Ulinastatin on Postoperative Stress and Inflammatory Reaction of 62Patients with Esophageal Cancer

Objective:To observe the effects of ulinastatin on the stress and inflammatory reactions of patients with esophagealcancer after resection.Methods:124 patients with esophageal cancer undergoing radical surgery in Department of Thoracic Surgery ofour hospital from January 2014 to March 2015 were collected and randomly divided into the observation group and the control group,with 62 cases in each group. The patients in the observation group were treated with ulinastatin the day after the surgery, while thepatients in the control group were treated with the regular anti-infectious methods. Then the changes of stress and inflammatory factors inthe two groups before and after the operation were compared.Results:The levels of NE, E, Cor, TNF-alpha, IL-6 and IL-8 of the two groups3 d after the surgery were significantly higher compared with those before the surgery (P<0.05). The increase in control group wasobviously higher than that in the observation group, and the difference was statistically significant (P<0.05). The occurrence rate ofcomplication in observation group and control group was 8.06%and 19.35%, respectively, and the difference was statistically significant(P<0.05).Conclusion:Thoracotomy resection in esophageal carcinoma patients can cause systemic inflammatory response, and theapplication of ulinastatin can inhibit the postoperative release of inflammatory factors and reduce the postoperative stress, which plays apositive role in reducing the occurrence rate of complication and promoting rehabilitation.