CD90在肝细胞肝癌组织中的表达及其与肝癌临床病理特征的关系

目的:探讨CD90在肝细胞肝癌(HCC)患者肿瘤组织中的表达及其与临床病理参数的关系,为HCC的临床治疗提供参考。方法:选择2014年3月-2015年3月在我院接受治疗的HCC患者80例,收集患者肿瘤组织及癌旁组织,另选择同期就诊的80例正常肝脏组织作为对照组。观察并比较CD90在肝癌组织、癌旁组织及正常肝脏组织中的表达情况。结果:CD90在肝癌组织、癌旁组织及正常肝脏组织中呈不同程度阳性表达(P0.05)。CD90在肝癌组织和癌旁组织中的表达显著高于正常肝脏组织,差异具有统计学意义(P0.05)。CD90在肝癌组织中的表达显著高于癌旁组织,差异具有统计学意义(P0.05)。CD90在HCC组织中的表达与肿瘤大小、肝内转移、TMN分期和病理分级有关(P0.05)。结论:CD90在肝癌组织中呈高表达,其表达水平与肝癌临床病理参数有关,可以作为HCC诊断、治疗及预后评估的参考指标。

Expressions of CD90 in Hepatocellular Carcinoma and the Relationshipwith Clinical Pathological Features

Objective:To explore the expressions of CD90 in hepatocellular carcinoma and the relationship with clinicalpathological parameters in order to provide a reference for clinical researches.Methods:80 patients with hepatocellular carcinoma whohad taken the resection surgery in our hospital from March 2014 to March 2015 were selected, and the HCC cancer tissues and thepara-carcinoma tissues were collected. Another 80 normal liver tissues were collected as the control group. Then the expressions in thetumor tissues, the para-carcinoma tissues and the normal tissues were detected and the relationship with clinical pathological parameterswas analyzed.Results:There were statistically significant differences about the expressions of CD90 in the tumor tissues, thepara-carcinoma tissues and the normal tissues (P<0.05). The expressions of CD90 in HCC tissues and para-carcinoma tissues were higherthan that of the normal tissues (P<0.05). The expression of CD90 in HCC tissues was higher than that of the para-carcinoma tissues (P<0.05). The expression of CD90 in HCC tissues was relative with the tumor size, the intrahepatic metastasis, the TMN stages and thepathological grades (P<0.05).Conclusion:The expression of CD90 increased in cancer tissues, which is closely relative with clinicalpathological parameters of HCC, that could provide a reference for diagnosis, treatment and prognosis of patients.