Association study of folate-related enzymes (MTHFR,MTR, MTRR) genetic
variants with non-obstructive male infertility in a Polish population |
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| Authors: | Mateusz Kurzawski Anna Wajda Damian Malinowski Anna Kazienko Rafal Kurzawa Marek Drozdzik |
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| Institution: | 1.Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.;2.Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland.;3.Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland. |
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| Abstract: | Spermatogenesis is a process where an important contribution of genes involved in
folate-mediated one-carbon metabolism is observed. The aim of the present study was
to investigate the association between male infertility and the
MTHFR (677C > T; 1298A > C), MTR (2756A
> G) and MTRR (66A > G) polymorphisms in a Polish population.
No significant differences in genotype or allele frequencies were detected between
the groups of 284 infertile men and of 352 fertile controls. These results
demonstrate that common polymorphisms in folate pathway genes are not major risk
factors for non-obstructive male infertility in the Polish population. |
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| Keywords: | MTHFR MTR MTRR polymorphism infertility |
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