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A new chemical tool for exploring the physiological function of the PDE2 isozyme |
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| Authors: | Chambers Robert J Abrams Kristin Garceau Norman Y Kamath Ajith V Manley Christopher M Lilley Susan C Otte Douglas A Scott Dennis O Sheils Alissa L Tess David A Vellekoop A Samuel Zhang Yan Lam Kelvin T |
| Affiliation: | Research Technology Center, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. Robert.J.Chambers@pfizer.com |
| Abstract: | Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2. |
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