Determination of 1,4- and 1,5-benzodiazepines in urine using a computerized gas chromatographic—mass spectrometric technique |
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Authors: | Hans Maurer Karl Pfleger |
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Affiliation: | Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, D-6650 Homburg (Saar G.F.R. |
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Abstract: | A method for the determination of benzodiazepines and their main metabolites in urine after acid hydrolysis is described. The extract is analyzed by computerized gas chromatography—mass spectrometry. An on-line computer allows rapid detection using mass fragmentography with the masses m/e 211, 230, 241, 244, 249, 262, 276, and 285. The mass fragmentogram and the underlying mass spectra of the hydrolysis products (benzophenones and analogues) are documented. |
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