Synaptotagmin in Ca2+ -dependent exocytosis: dynamic action in a flash |
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Authors: | Tokuoka Hirofumi Goda Yukiko |
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Institution: | MRC Cell Biology Unit and Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom. |
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Abstract: | Synaptotagmins have been the popular candidates for the Ca2+ sensor that couples local rise in Ca2+ to neurotransmitter release. Studies in worm, fly, and mouse corroborate the likely role for synaptotagmin I, the best-studied synaptotagmin prototype, as a Ca2+ trigger for synaptic vesicle exocytosis. Recent investigations have focused on structural domains of synaptotagmin that are critical for its function. Here we provide a brief overview of synaptotagmin I and discuss recent studies within the framework of neurotransmitter release mechanisms for fast synaptic transmission. |
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