首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Brain-stem trigeminal and auditory evoked potentials in multiple sclerosis: physiological insights
Institution:1. Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Boston, MA, USA;2. Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA;3. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;1. Division of Rheumatology, Azienda USL - Istituto di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, Viale Risorgimento 80, 42100 Reggio Emilia, Italy;2. Modena and Reggio Emilia University, Via Università 4, 41121 Modena, Italy;3. Campus Bio-Medico University of Rome, Via Álvaro del Portillo n° 200, 00128 Rome, Italy;4. Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Tel-Aviv University, Israel.;5. Department of Clinical and Experimental Medicine, University Hospital Gasthuisberg, Leuven, Flanders, Belgium
Abstract:Thirty-six patients with multiple sclerosis were evaluated by means of brain-stem trigeminal and auditory evoked potentials. The brain-stem auditory evoked potentials (BAEPs) were abnormal in 26 patients (72.2%). Brain-stem trigeminal evoked potentials (BTEPs) yielded similar results, showing distorted waveforms and/or prolonged latencies in 25 patients (69.4%). As expected, the MRI proved to be the most efficient single test, revealing plaques in 86.4% of the patients evaluated. However, the diagnostic accuracy of MRI was lower than that provided by the combination of the BTEP and the BAEP (88.9%). Moreover, in patients having signs of brain-stem involvement, the BTEP, alone and in combination with the BAEP, proved to be more sensitive than the MRI in revealing brain-stem lesions.Correlation between clinical and BTEP findings could be found only in those patients who presented with signs of trigeminal involvement such as trigeminal neuralgia or dysesthesiae. The analysis of the BTEP waveforms showed two distinct types of abnormality — a peripheral type and a central type — suggesting plaques in distinct locations.Both the BTEP and the BAEP demonstrated a correlation with the clinical course of the disease and the condition of the patient at the time of the evaluation. Relapse of the disease was associated with a marked prolongation of the central conduction time in the BTEP and in the BAEP, suggesting the application of such studies to the monitoring of unstable patients or the evaluation of new therapeutic protocols.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号