The effect of aging and pressure on the specific hydraulic conductivity of the aortic wall |
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| Affiliation: | 1. Institute of Biostructure and Bioimaging (CNR) c/o Molecular Biotechnologies Center, Via Nizza 52, 10126, Torino, Italy;2. Molecular Imaging Center, University of Torino, Via Nizza 52, 10126 Torino, Italy;3. Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy;4. Dept. of Computer Science, University College London, Gower Street, London WC1E 6BT, United Kingdom;1. Department of Intervetional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China;2. Department of Radiology, Shanghai jiao Tong University Affiliated Sixth People''s Hospital, Shanghai, China.;3. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China;4. Department of Protistology, Guangdong Jiaying Medical College, Meizhou, China;5. Siemens Shenzhen Magnetic Resonance Ltd, Siemens MRI Center, Shenzhen, China.;6. Cancer Research Institute, Shanghai Cancer Center, Fudan University, Shanghai, China;1. Cancer Center Amsterdam, Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands;2. Cancer Center Amsterdam, LEXOR (Laboratory for Experimental Oncology and Radiobiology), Academic Medical Center, Amsterdam, The Netherlands;3. Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands;4. Department of Radiation Oncology, Academic Medical Center, Amsterdam, The Netherlands;5. Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands |
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| Abstract: | We measured the specific hydraulic conductivity (K) of the human and bovine aortic wall, two tissues for which K has not been previously reported in the literature, and examined the effects of aging (human) and development (bovine) on K. As part of the study, we also examined the effects of mounting the tissue in a flat or cylindrical configuration and the effects of perfusion pressure. With aging, in the human, we found a modest increase of K with age in a flat geometry; this trend was not apparent in a limited number of measurements in a cylindrical geometry. No significant dependence of K on developmental stage was found in the bovine aortic wall perfused in either a flat or cylindrical geometry. Our results indicate that aging and developmental changes of the aortic extracellular matrix have minimal effects on its hydrodynamic transport properties as measured. Mounting geometry for the aorta has been a concern reported in the literature since Yamartino et al. (1974) reported that K in the rabbit was 10-fold lower when measured in a flat geometry than in a cylindrical geometry. We found mounting geometry to make only a small difference in the calf and the cow, (Kflat approximately 2/3 of Kcylindrical), and in the human, we found K to be somewhat higher in the flat geometry than in the cylindrical geometry. Higher perfusion pressures decreased K of bovine tissue in the flat geometry, but pressure was not found to have a significant effect on K in the cylindrical geometry. An analytical model demonstrated that the anisotropic nature of the aortic wall allows it to be compressible (water-expressing) and yet remain at nearly constant tissue volume as the aorta is pressurized in a cylindrical geometry. |
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