Synthesis and evaluation as glycosidase inhibitors of 2,5-imino-D-glucitol and 1,5-imino-D-mannitol related derivatives |
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| Authors: | McCort I Fort S Duréault A Depezay J C |
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| Affiliation: | University René Descartes, Laboratoire e Chimie et Biochimie Pharmacologiques et Toxicologiques, associé au CNRS, Paris, France. mccort@biomedicale.univ-paris5.fr |
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| Abstract: | Selectively functionalized 2,5-imino-D-glucitol and 1,5-imino-D-mannitol derivatives were synthesized and tested as precursors of hydrolytically resistant pseudo-disaccharides. Among them N-acetyl-6-amino-6-deoxy-2,5-imino-D-glucitol (11) and N-acetyl-6-amino-6-deoxy-1,5-imino-D-mannitol (12) were found potent and specific inhibitors against beta-D-glucosidase and alpha-L-fucosidase, respectively. |
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