Myelin-associated glycoprotein-mediated signaling in central nervous system pathophysiology |
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Authors: | Yanan Chen Selina Aulia Bor Luen Tang |
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Institution: | (1) Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore |
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Abstract: | The myelin-associated glycoprotein (MAG) is a type I membrane-spanning protein expressed exclusively in oligoden drocytes
and Schwann cells. It has two generally known pathophysiological roles in the central nervous system (CNS): maintenance of
myelin integrity and inhibition of CNS axonal regeneration. The subtle CNS phenotype resulting from genetic ablation of MAG
expression has made mechanistic analysis of its functional role in these difficult. However, the past few years have brought
some major revelations, particularly in terms of mechanisms of MAG signaling through the Nogo-66 receptor (NgR) complex. Although
apparently converging through NgR, a readily noticeable fact is that the neuronal growth inhibitory effect of MAG differs
from that of Nogo-66. This may result from the influence of coreceptors in the form of gangliosides or from MAG-specific neuronal
receptors such as NgR2. MAG has several other neuronal binding partners, and some of these may modulate its interaction with
the NgR complex or downstream signaling. This article discusses new findings in MAG-forward and-reverse signaling and its
role in CNS pathophysiology. |
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Keywords: | Axonal regeneration myelin myelin-associated glycoprotein Nogo-66 receptor (NgR) p75NTR |
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