雷贝拉唑联合莫沙必利治疗反流性食管炎的临床疗效观察

目的:治疗雷贝拉唑联合莫沙必利治疗返流性食管炎的临床疗效。方法:108例反流性食管炎患者随机分成两组,治疗组56例和奥美拉唑对照组52例,治疗组应用雷贝拉唑和莫沙必利,对照组应用奥美拉唑和莫沙必利,观察治疗前后患者的临床症改善和内镜变化。结果:治疗8周,治疗组症状积分明显优于对照组(P<0.05),治疗组疗效明显优于对照组(P<0.05),胃镜检查结果示治疗组食管黏膜愈合情况优于对照组(P<0.5)。结论:雷贝拉唑和莫沙必利联用治疗反流性食管炎临床症状明显改善,联合用药临床疗效优于奥美拉唑。

The Efficacy of Rabeprazole Combined with Mosapride in the Treatment of Reflux Esophagitis

Objective: To observe the efficacy of rabeprazole combined with mosapride in the treatment of reflux esophagitis(RE).Methods: 108 cases of RE was randomized to two groups,56 cases in treatment group and 52 cases in control group.The treatment group was treated with rabeprazole and mosapride.The control group was treated with omeprazole and mosapride.The change in symptom and endoscope before and after treatment were observed.Results: After treated for 8 weeks,the score of symptom had been improved ob-viously in treatment group(P<0.05).And the total effective rate was better in treatment group than control group(P<0.05).Esophageal mucosa concrescence was significantly better in treatment group.There was difference between the two groups(P<0.05).Conclusion: The clinical symptoms of RE were markedly improved after treatment of rabeprazole combined with mosapride.Its efficacy is better than that of omeprazole combined with mosapride.