多原发癌

目的:探讨多原发癌的病因、临床特点及其诊治。方法:回顾性总结分析了一组普通外科多原发癌病人的资料,并结合文献进行了分析。结果:本组77例多原发癌,占同期普通外科住院病人的1.33%(77/5768),半数以上发生于65岁及以上的老年人。胃肠道多原发癌占81.8%。其发生主要与下列因素有关:基因缺陷因素(遗传易感性)、环境因素、治疗所致(如放、化疗)、免疫缺陷、老龄。结论:多原发癌近年呈增加趋势,对于肿瘤病人的诊治,不要忽略了同时性癌的可能;手术仍是多原发癌实体瘤主要而有效的治疗手段。

Multiple PrimaryMalignancies

Objective:To investigate the etiology,clinical characteristics,and management of multiple primary malignancies(MPM).Methods: A group of 77 patients with MPM were treated in the general surgery department from May 2002 to April 2007.Results: These patients accounted for 1.3% of hospitalized patients(77/5768) in the general surgery department from May 2002 to April 2007.Half of them were more than 65 years old;gastrointestinal MPM accounted for 81.8% of the cases(63/77).The related factors are genetic defects,environmental factors,medical treatments(such as radiotherapy and chemotherapy),immunity defects and advanced age.Conclusion: The incidence of MPM is increasing in recent years.The possibility of synchronous/metachronous carcinomas should not be overlooked during treatment for cancer or when patients return for further consultation.Resection is the primary therapeutic measure for solid MPM tumors.