老年痴呆与血浆同型半胱氨酸水平关系的临床研究

目的:探讨血浆同型半胱氨酸(homocysteine,Hcy)水平与老年痴呆的相关性。方法:应用全自动生化分析仪以循环酶法检测90例老年痴呆患者的血浆Hcy浓度,并与30例非痴呆患者作为同龄对照组血浆Hcy浓度进行比较;根据Hachinski缺血指数量表评分将老年痴呆分为阿尔茨海默病(Alzheimer’s disease,AD),混合性痴呆(mixed dementia,MD),血管性痴呆(vascular dementia,VD);根据简易精神状态检查量表(Mini-Mental State Examination,MMSE)评分划分痴呆患者严重程度,分为轻度、中度、重度。结果:AD、MD、VD组血浆Hcy水平均显著高于对照组(P<0.01);不同程度痴呆患者血浆Hcy水平有显著性差异(P<0.05),血浆Hcy浓度越高,认知功能损害的程度越重。结论:高Hcy血症可能是老年期痴呆发病的一个重要危险因素,且认知功能减退的程度与血浆同型半胱氨酸浓度呈正相关。

The Clinical Research of Plasma Homocysteine Levels in Senile Dementia

Objective:To investigate the relationship between plasma homocystetine(Hcy) level and dementia.Methods: The plasma Hcy levels in 90 cases of senile dementia and 30 non-demented controls were determined by automatic biochemical analyzer with enzymatic cycle detection.According to Hachinski ischemic score patients were divided into Alzheimer’s disease(Alzheimer’s Alzheimer disease,AD),mixed dementia(mixed dementia,MD),vascular dementia(vascular dementia,VD).The severity of dementia patients were classi-fied by MMSE’s scores: mild.moderate and severe.Results: Mean total plasma Hcy concentrations were significantly higher in AD.MD.VD patients than that in the patients with non-demented patients(P<0.01).Plasma Hcy was different significantly in dementia patients with different severities of cognitive disorder(P<0.05).The higher the plasma Hcy concentration,the more severe of degree of cognitive dysfunction.Conclusion: Hyperhomocysteinemia(Hhcy) may be an important risk factor of senile dementia.Hcy level is positively corre-lated with the severity of cognitive disorder in patients with dementia.