| 创新药物体外ADMET 的高通量筛选技术研究进展 |
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| 引用本文： | 邓志婷戚欣李静. 创新药物体外ADMET 的高通量筛选技术研究进展[J]. 现代生物医学进展, 2012, 12(6): 1176-1178 |
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| 作者姓名： | 邓志婷戚欣李静 |
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| 作者单位： | 海洋药物教育部重点实验室中国海洋大学医药学院 |
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| 基金项目： | 国家高技术研究发展计划(863计划)资助项目(2007AA09Z405) |
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| 摘 要： | 目前的新药研发策略已从传统的以活性为主导的筛选模式,转变为在测定药效的同时平行评价化合物的ADMET性质,并建立了系列体外ADMET高通量筛选技术。本文综述了近年来药物体外ADMET高通量筛选技术的研究进展。
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| 关 键 词： | 高通量筛选 理化性质 ADMET |
High Throughput Screening of in Vitro ADMET Profiling inDrug Discovery |
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| DENG Zhi-ting,QI Xin,LI Jing. High Throughput Screening of in Vitro ADMET Profiling inDrug Discovery[J]. Progress in Modern Biomedicine, 2012, 12(6): 1176-1178 |
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| Authors: | DENG Zhi-ting QI Xin LI Jing |
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| Affiliation: | (Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy of Ocean University of China,Qingdao Shandong,266003,China) |
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| Abstract: | Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important role in drug discovery and development.In this review,we summarize state of the high throughput assays for screening of key physicochemical properties such as pKa,lipophilicity and solubility as well as in vitro ADMET profiling. |
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| Keywords: | High throughput screening Physicochemical property ADMET |
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