福坦治疗高原心脏病的临床观察

目的:观察福坦治疗高原心脏病的临床疗效。方法:选择我院2007年10月至2010年10月收治的高原心脏病伴右心衰患者86例,随机分为试验组和对照组,试验组42例给予福坦治疗,对照组44例给予卡托普利加氢氯噻嗪治疗,治疗周期为1年。比较2组治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、短轴缩短率(FS)、射血分数(LVEF)及6分钟步行前后心率、血压、心肌耗氧量并进行统计学分析。结果:试验组LVEF明显增加,LVEDD、LVESD明显减小,心率、心肌耗氧量的降低,较对照组具有统计学差异。结论:福坦具有明显的抗高原心脏病的作用。

Clinical Study on Valsartan and Hydrochlorothiazide Tablets(VHT)in the Treatment of HAHD

Objective: To investigate the effects of Valsartan and Hydrochlorothiazide Tablets in the treatment of HAHD.Method: 86 cases of hospitalization in HAHD patients combined with right heart failure would be divided into treatment group(n=42) and control group(n=44).The treatment group was given Valsartan and Hydrochlorothiazide tablets(VHT),and the control group was given Captopril plus Hydrochlorothiazide.Left ventricular end diastolic dimension(LVEDD),left ventricular end-systolic dimension(LVESD)and left ventricular ejection fraction(LVEF) as wel1 as heart rate,systolic pressure,6-minute walking testwere evaluated before and after treatment.Results: After 12 months of treatment,LVFF and 6-min walking test were improved(P<0.05).The heart rate,systolic pressure,LVEDD and LVESD in the observation group were decreased significantly(P<0.05).There was significant difference between 2 groups(all P<0.05).Conclusion: VHT can obviously improve HADHD.