| 基质金属蛋白酶-9 与全身炎症反应综合征研究进展 |
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| 引用本文： | 王鹏,余旻,王嘉军.基质金属蛋白酶-9 与全身炎症反应综合征研究进展[J].现代生物医学进展,2012,12(5):998-1000. |
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| 作者姓名： | 王鹏 余旻 王嘉军 |
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| 作者单位： | 1. 三峡大学人民医院 湖北宜昌443000
2. 三峡大学医学院 湖北宜昌443000 |
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| 基金项目： | 湖北省自然基金资助项目(2009CDZ029) |
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| 摘 要： | 全身炎症反应综合征是引发多器官功能障碍综合征的主要原因,而其发生的关键环节是血管内皮细胞的损伤。内皮细胞外基质是内皮细胞生存的依托,其主要成分为IV型胶原。基质金属蛋白酶-9可以降解IV型胶原,破坏内皮细胞外基膜。本文综述了基质金属蛋白酶-9与全身炎症反应的关系。
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| 关 键 词： | 基质金属蛋白酶-9 全身炎症反应综合征 多器官功能障碍综合征 细胞外基质 |
Progress in Correlation between Matrix Metalloproteinase - 9
and Systemic Inflammation Response Syndrome |
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| WANG Peng,YU Min,WANG Jia-jun.Progress in Correlation between Matrix Metalloproteinase - 9
and Systemic Inflammation Response Syndrome[J].Progress in Modern Biomedicine,2012,12(5):998-1000. |
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| Authors: | WANG Peng YU Min WANG Jia-jun |
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| Institution: | 1 Pepole’s Hospital of Three gorges university,443000,Yichang Hubei,China; 2 Medical School,Three gorges university,443002,Yichang Hubei,China) |
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| Abstract: | Systemic inflammation response syndrome(SIRS) is the leading cause of multiple organ dysfunction syndrome(MODS).The normal function of the endothelial cells depend on extracellular matrix(ECM) whose important component is the collagen IV(IV-C).ECM could be damaged by Matrix metalloproteinase-9(MMP-9) for inducing the degradation of IV-C.This paper briefly review relative reports on the correlation between MMP-9 and SIRS. |
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| Keywords: | Matrix metalloproteinase-9 Systemic inflammation response syndrome Multiple organ dysfunction syndrome Extracellular matrix |
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