Foxj1 在脑外伤后的表达变化

目的:探讨脑外伤后Foxj1在脑组织中的表达变化及其意义。方法:建立大鼠脑外伤模型,利用Western blot和免疫组织化学方法检测脑外伤后Foxj1在脑组织中表达的变化。结果:Western blot显示大鼠脑外伤后,Foxj1的表达逐步增高,伤后3 d升至最高点,之后逐渐降低;免疫组织化学的结果与Western blot一致。结论:脑外伤后Foxj1在脑组织中的表达增高,这种增高的表达参与了脑外伤后脑组织的病理生理和生化变化。

The Expression of Foxj1 after Traumatic Brain Injury

Objective: The goal of this study was to evaluate the expression of Foxj1 in the central nervous system after Traumatic Brain Injury.Methods: The brain stab-injury models of rat were performed.Western blot and immunohistochemistry analysis were used to investigate the expression of Foxj1 at various times after injury.Results: Foxj1 proteins around lesion site increased gradually and reached its maximum at the 3d post-injury,after that,the expression level began to decline.Immunohistochemistry showed similar results as Western blot.Conclusions: The increased expression of Foxj1 may be involved in the pathophysiological and biochemical progression after Traumatic Brain Injury.