| 第三代测序基本原理 |
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| 引用本文： | 李明爽赵敏. 第三代测序基本原理[J]. 现代生物医学进展, 2012, 12(10): 1980-1982 |
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| 作者姓名： | 李明爽赵敏 |
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| 作者单位： | 东北林业大学 黑龙江哈尔滨150040 |
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| 摘 要： | 文章阐述了以单分子实时测序和纳米孔技术为标志第三代测序的基本原理,介绍了Helicos的Heliscope单分子测序仪、Pacific Bioscience的SMRT技术和Oxford Nanopore Technologies公司正在研究的纳米孔单分子测序技术。与其他测序技术进行了简单的对比以并提出一些单分子测序仍需面对的问题以及对未来单分子测序的展望。
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| 关 键 词： | 第三代测序 原理 问题 |
The Mechanisms of the Third Generation Sequencing Technology |
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| LI Ming-shuang,ZHAO Min. The Mechanisms of the Third Generation Sequencing Technology[J]. Progress in Modern Biomedicine, 2012, 12(10): 1980-1982 |
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| Authors: | LI Ming-shuang ZHAO Min |
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| Affiliation: | (Northeast Forestry University,Harbin 150040,China) |
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| Abstract: | In this review,I describe the mechanisms and features of the third generation sequencing technology which is a new generation of single molecule sequencing technology,introduce the True Single Molecule Sequencing(tSMSTM) of Helicos,the Single Molecule Real Time(SMRTTM) DNA Sequencing of the Pacific Bioscience,and the single-molecule nanopore DNA sequencing of the Oxford Nanopore Technologies.The advantages compared with the second generation sequencing,the problems and its future persp-ectives will be discussed here. |
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| Keywords: | The third generation sequencing Mechanisms Problems |
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