血清胱抑素C 检测在ICU 急性肾损伤中的意义

目的:测定ICU的急性肾损伤(AKI)患者和ICU非AKI患者的血清胱抑素C(Cys C)、Cr及β2-MG的水平,研究Cys C在AKI中的应用价值。方法:采用日立7600-120全自动生化分析仪测定ICU AKI患者31例和ICU非AKI患者24例的Cys C、Cr、β2-MG,用受试者工作曲线(ROC)评价Cys C的诊断价值,采用spss 16.0统计软件包进行统计分析。结果:ICU的AKI患者的血清Cys C水平较ICU非AKI对照组升高,有统计学意义,Cys C]-1与eGFR呈正相关,r=0.711,P<0.001;与AKI分期无统计学意义。ROC曲线分析证实Cys C在AKI的诊断中敏感性和特异性最好。结论:血清Cys C可以做为ICU病人发生AKI的诊断指标,为AKI的及时诊断、肾功能的评估提供了可靠的依据,有助于临床更好的把握治疗时机。

The Application of Cystatin C (Cys C) in Valuation Acute Kidney Injury in ICU Patients

Objective: To explore the application of Cystatin C(Cys C) in valuation acute kidney injury in ICU Patients.Methods: In this study,55 patients were collected and divided into two groups,including 31 cases with AKI and 24 cases without AKI as controls.We measured the serum concentration of Cys C,β 2-MG,and Cr by HITACHI 7600-120 Automatic biochemical analyzer.The eGFR was estimated the with MDRD equation.Then compared Cys C、Cr、β 2-MG between two groups and the correlations with each other.The diagnostic value of Cys C were evaluated by ROC curve with SPSS 16.0 software.Results: In AKI group,The serum level of Cys C were significantly higher than that in non-AKI group(P<0.05),it has no significant difference among three periods(P>0.05).-1 was also positively correlated with eGFR(r=0.711,P<0.001).The ROCAUR of Cys C is 0.930.Conclusions: Cys C is a very useful diagnostic indicator in AKI,especially in the early diagnose AKI,it could provide a reliable assessment of renal function and grasp the right opportunity to better treatment.