非小细胞肺癌的治疗方案及影响预后的重要因素

目的:回顾分析各种非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗方案及影响其治疗预后的因素,为合理制定个体化的综合治疗方案提供参考。方法:回顾分析近年来NSCLC治疗的研究报道,分析如病理分期、实验室检查结果(VEGF、WBC、Hg等)影响治疗预后的因素,建议相应的治疗对策。结果:1.Ⅰ期、Ⅱ期及部分Ⅲa期NSCLC的患者治疗措施首先以手术治疗为主,同步放化疗比单纯放、化疗及序贯放化疗更能有效改善晚期NSCLC的预后;2.个体相关因素、肿瘤相关因素和治疗相关因素影响NSCLC治疗预后。结论:同步放化疗在晚期NSCLC的治疗中有重要作用,肿瘤的病理分期、血浆VEGF浓度是影响NSCLC预后的独立因素。

Treatment of Non-small Cell Lung Cancer andthe Important Prognostic Factors

Objective: To analyze treatment options of non-small cell lung cancer(NSCLC) and the factors affecting the prognosis,in order to provide a comprehensive reference to develop individualized treatment programs.Methods: Review the recent research reports of NSCLC treatment.Analyze the role of influencing factors such as tumor staging,laboratory test results(VEGF,WBC,Hg,etc.) in tumor therapy.Suggest the appropriate therapeutic strategies.Results: 1).The first treatment option to NSCLC patients with stageⅠ,Ⅱ,Ⅲa are surgical treatment.Concurrent chemo-radiation is more effective in improving the prognosis of advanced NSCLC than simply radiotherapy or chemotherapy and sequential chemo-radiation.2).Individual factors,tumor-associated factors and treatment-related factors affect the prognosis of NSCLC treatment.Conclusion: Concurrent chemo-radiation has an important role in the treatment of advanced NSCLC.Tumor staging and plasma VEGF concentration are independent prognosis factors of NSCLC.