HCN 通道在生物胃肠道起搏机制中作用研究现状

HCN通道(hyperpolarization-activated cyclic nucleotide-gated channels)是一种超极化激活的,钠、钾、钙离子混合通透的,直接受cAMP调控的离子通道,在人体内的分布具有一定的组织和细胞特异性,其不仅与神经系统疾病联系紧密,与胃肠道动力障碍疾病也存在一定联系。对HCN通道生理功能、在胃肠起搏电流形成中作用及与疾病的关系的深入了解,必将对今后的研究以及临床治疗有实际意义。

Research on the Function of HCN Channels in Pace-making Mechanisms ofBiological Gastrointestinal Tract

Hyperpolarization-activated cyclic nucleotide-gated channels are hyperpolarization-activated ion channels which can be regulated directly by cAMP and penetrated by Na+,Ka+ and Ca2+.The distribution of the HCN channels in human body shows certain specificities in tissues and cells.They are not only in close relevance with nerve system diseases,but also in connection with gastrointestinal motility diseases.A deepgoing understanding of the physiological functions of HCN channels、the role in the formation of pacemaker current and relation with diseases will undoubtedly have practical significance for the researches and clinical treatments in the future.