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ω-3 多不饱和脂肪酸对PTSD-SPS 大鼠行为学影响的研究
引用本文:朱敏,王彬,王枫,郑刚,张雪平.ω-3 多不饱和脂肪酸对PTSD-SPS 大鼠行为学影响的研究[J].现代生物医学进展,2012,12(12):2290-2293.
作者姓名:朱敏  王彬  王枫  郑刚  张雪平
作者单位:1. 第四军医大学军事预防医学院营养与食品卫生学教研室
2. 第四军医大学军事预防医学院劳动卫生与环境卫生学教研室 陕西西安710032
基金项目:国家自然科学基金(30972428)
摘    要:目的:观察饲料中添加ω-3PUFAs对PTSD-SPS大鼠焦虑/抑郁行为的防护作用。方法:将40只健康成年雄性SD大鼠随机分为正常对照组、PTSD-SPS模型组、60%ω-3PUFAs+PTSD-SPS模型组1、60%ω-3PUFAs+PTSD-SPS模型组2。采用高架十字迷宫实验和旷场实验评价实验组大鼠的焦虑/抑郁行为变化。结果:与对照组相比,SPS模型组大鼠进入开放臂的次数比例和时间比例明显减少;中央格停留时间明显缩短(5.56±0.21)s,穿格次数明显减少(30.23±5.96)次,差异均显著(P<0.05)。与SPS模型组相比,60%ω-3PUFAs的SPS组大鼠进入开放臂的次数比例和时间比例明显增加;中央格停留时间明显延长(9.88±1.14)s,穿格次数明显增加(43.22±4.35)次,差异均显著(P<0.05);与对照组相比没有显著差异。结论:膳食补充ω-3多不饱和脂肪酸可以降低PTSD-SPS大鼠焦虑/抑郁程度。

关 键 词:PTSD  ω-3多不饱和脂肪酸  高架十字迷宫实验  旷场实验

Effects of w-3 Polyunsaturated Fatty Acids on Behavioral Changes of Rats with PTSD-SPS
ZHU Min,WANG Bin,WANG Feng,ZHENG Gang,ZHNAG Xue-ping.Effects of w-3 Polyunsaturated Fatty Acids on Behavioral Changes of Rats with PTSD-SPS[J].Progress in Modern Biomedicine,2012,12(12):2290-2293.
Authors:ZHU Min  WANG Bin  WANG Feng  ZHENG Gang  ZHNAG Xue-ping
Institution:ZHU Min1,WANG Bin1,WANG Feng1,ZHENG Gang2,ZHNAG Xue-ping1△(1 Department of Nutrition and Food Hygiene; 2 Department of Occupational and Environmental Health;Fourth Military Medical University,Xi’an 710032,China)
Abstract:Objective: To investigate the effects of w-3PUFAs on the anxiety and depression-like behaviors of rats with PTSD-SPS.Methods: Forty male SD rats were randomly and equally divided into 4 groups: control group,PTSD-SPS group,60 % w-3PUFAs + PTSD-SPS group 1,60 % w-3PUFAs + PTSD-SPS group 2.The behavioral changes were evaluated by the EPM test sys-tem and the OF test system.Results: In the EPM test,the number of entering the open-arm and the open-arm detention time in the PTSD-SPS group were significantly lower than that of the control group(P<0.05).The time of resting on the center lattice and times of spanning lattice in the SPS group decreased(5.56 ± 0.21) s and(30.23 ± 5.96) times in the OF test(P<0.05),respectively.The num-ber of entering the open-arm and the open-arm detention time in the w-3PUFAs group were significantly lower than that of the SPS group(P<0.05) in the EPM test.The time of resting on the center lattice and times of spanning lattice were increased(9.88 ± 1.14) s and(43.22 ±4.35) times in the OF test(P<0.05),respectively.There were no significance difference between the w-3PUFAs group and the control group.Conclusion: Dietary Supplement of w-3PUFAs could reduce the anxiety and depression-like behaviors of PTSD-SPS model rats.
Keywords:PTSD  w-3 polyunsaturated fatty acids  Elevated plus maze test  Open-field test
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