肾素- 血管紧张素- 醛固酮系统与原发性高血压病的关系

目的:探讨血浆肾素-血管紧张素系统与原发性高血压病的关系。方法:采用病例-对照研究设计,入选125例原发性高血压病患者与60例血压正常健康体检者为对照组。采用放射免疫方法测定立位、卧位血浆肾素活性(PRA),醛固酮(ALD)浓度及血管紧张素Ⅱ(AngⅡ)浓度。结果:原发性高血压患者,立位、卧位血浆PRA均低于正常对照组(P<0.05),而ALD浓度及AngⅡ浓度均高于正常对照组(P<0.05)。根据高血压病1级、2级、3级分组,立位、卧位血浆PRA均依次降低(P<0.05);而ALD浓度及AngⅡ浓度依次升高(P<0.05)。结论:肾素-血管紧张素-醛固酮系统与原发性高血压病的发病关系密切,血浆PRA水平、AngⅡ及ALD浓度有望成为原发性高血压病分级的有效指标;降低原发性高血压患者AngⅡ及ALD量是治疗高血压病的关键,血浆AngII、ALD也有望成为评价原发性高血压病疗效的指标。

The Correlation between Essential Hypertension and Renin-angiotensin-aldosterone System

Objective: To assess the correlation between essential hypertension and renin-angiotensin-aldosterone system(RAAS) in patients.Methods: Using a case-control study design,125 patients with essential hypertension were compared to 60 control patients.The plasma levels of renin activity(PRA),angiotensinⅡ(AngⅡ) and aldosterone(ALD) were measured by radioimmunoassay(RIA).Results: The plasma levels of PRA in the hypertensive patients were significantly lower than that of the controls(P<0.05),but the plasma levels of AngⅡ and ALD were higher(P<0.05).With the severity of their blood pressure,the plasma levels of PRA decreased,but the plasma levels of AngⅡand ALD increased,and showed statistical differences between the groups(P<0.05).Conclusion: There was a strong association between essential hypertension and RAAS.PRA,AngⅡ and ALD hopefully served as a effective index of hypertensive classification.The reductions of AngⅡ and ALD are critical events in the treatment of hypertension,and that maybe served as parameters representing the therapeutic efficacy.