超声介导镇痛药物透皮吸收研究进展

现阶段,临床中常用的镇痛药物多采用口服或注射给药的方式,具全身不良反应多,患者依从性差等缺点,透皮给药作为一种非侵入性给药方式,相对于这些有很多显著的优势,如使用方便,患者痛苦少等。但是,如何克服皮肤的低渗透性一直是该种给药方式发展的瓶颈。近年来,使用超声能量增强镇痛药物在皮肤上的的渗透性成为新的研究热点,各项研究发现,低频超声对药物的增透效果尤为显著。本文通过检索各国文献,对超声介导镇痛药物透皮吸收的原理,临床前试验和临床试验进行综述。

The new study of Ultrasound-Mediated Transdermal Analgesic Drugs

Resently,the most of analgesic drugs used in oral or injection have lots of disadvantagement such as adverse reactions,poor patient compliance and so on.Transdermal drug delivery,a non-invasive drug delivery,has many significant advantages compared to the the traditional drug delivery.However,how to overcome the low permeability of the skin is the bottleneck of ultrasound-mediated transdermal.In recent years,enhance analgesic drugs permeability of the skin by ultrasonic energy become a new hotspot.Many researches found that the drug effect of low-frequency ultrasound to increase the permeability is particularly significant.This literature reviews the principles,pre-clinical trials and clinical trial of ultrasound-mediated transdermal analgesic.