多西紫杉醇联合适形放疗治疗老年贲门癌患者的疗效观察

目的:探讨周剂量多西紫杉醇联合三维适形放疗(3DCRT)治疗进展期贲门癌患者的疗效。方法:2007年10月到2009年5月38例不能手术的贲门癌患者行3DCRT,处方剂量62Gy,1.8Gy/次,5次/周;同时联合多西紫杉醇75mg/m2,每周1次,连续6周。用Kaplan-Meier法分析患者的中位无进展生存时间。结果:完全缓解12例,部分缓解18例,30名患者缓解(78.9%),中位无进展生存时间16.4个月。治疗过程中的毒副作用轻,患者可以耐受。结论:周剂量多西紫杉醇化疗联合适形放疗对进展期贲门癌患者是安全、有效的。

Weekly Docetaxel and Concomitant Radiotherapy for the Elderly Patients with Unresectable Gastric Cancer

Objective: To explore the efficacy of weekly docetaxel and concurrent 3DCRT in treatment of elderly patients with unresectable gastric cancer.Methods: During October 2007 to May 2009,38 patients treated with 3DCRT(62 Gy in fractions of 1.8Gy daily,five times weekly) and concurrent docetaxel(75 mg/m2,one time per week for successive six weeks).The Kaplan-Meier method was used to evaluate the median progression-free survival time.Results: Complete response and partial response were observed in 78.9% of patients.The overall median progression-free survival time was 16.4 months.Toxicities are tolerable.Conclusions: The therapy of 3DCRT plus concomitant chemotherapy based on docetaxel weekly was effective and safe for the treatment of unresectable gastric cancer.