硝苯地平联合缬沙坦治疗老年原发性高血压疗效分析

目的:探讨硝苯地平缓释片联合缬沙坦治疗老年原发性高血压的临床疗效。方法:将180例患者随机分入对照组与观察组,给予对照组86例患者硝苯地平缓释片口服降压;观察组94例患者接受硝苯地平缓释片联合缬沙坦治疗,比较两组患者治疗8周后血压、心率、脉压、肾功、尿酸、血钾及尿微量白蛋白的变化。结果:治疗后观察组患者收缩压、舒张压、脉压及心率均显著降低,治疗总有效率高于对照组,两组比较差异有统计学意义(P<0.01);观察组尿酸、尿微量白蛋白显著优于对照组(P<0.01),两组肾功、血钾比较差异无统计学意义(P>0.05)。结论:硝苯地平缓释片联合缬沙坦治疗老年原发性高血压,降压平稳,同时可显著降低尿酸及尿微量白蛋白,改善肾功能。

Therapeutic Effect of Valsartan Combined with Sustained- release Nifedipine on Elderly Hypertension

Objective: To explore therapeutic effect of valsartan combined with sustained-release nifedipine on elderly hypertension.Methods: 180 cases with elderly hypertension were divided into control group and experience group.86 cases of control group took sustained-release nifedipine and 94 cases of experience group were treated with valsartan and sustained-release nifedipine.Blood pressure,heart rate,pulse pressure,renal function,uric acid,serum potassium and urinary albumin were compared between two groups 8 weeks after treatment.Results: Systolic pressure,diastolic pressure,pulse pressure and heart rate strikingly decreased and total effective rate was much higher in experience group than that in control group(P<0.01);Uric acid and urinary albumin in experience group was superior to that in control group(P<0.01);There were no significant differences between the two groups in neither renal function nor serum potassium(P>0.05).Conclusion: Valsartan combined with nifedipine sustained-release on elderly hypertension can steady blood pressure,significantly decrease uric acid and urinary albumin and improve renal function.