白血病干细胞自我更新信号通路相关基因表达与白血病复发

除骨髓移植外,以化疗为主的急性白血病治愈率很低,尤其因耐药复发的难治性急性白血病不能治愈的原因是患者体内存在一群具有自我更新能力的白血病干细胞。虽然这些细胞数量极少,但可自我更新,具有很强的增殖潜能,在白血病发生和复发过程中起着关键性作用。白血病干细胞的存在和增殖受细胞表面分子、细胞调控信号通路、细胞自我更新信号通路与骨髓微环境等多因素影响,其中,细胞自我更新信号通路及其相关基因表达在维系白血病干细胞生物学特征方面发挥着重要作用

The Gene Expression of Self-renewal Signal Pathways in Leukaemia Stem Cells and Leukemia Relapse

In addition to the bone marrow transplantation,the cure rate of acute leukemia mainly with chemotherapy is very low.Especially because of the acute leukemia of drug resistance relapsing refractorily cannot be cured is existing self-renewal ability of leukaemia stem cells of a group of patients.Although these very few number of cells can self-renewal,and have a strong potential prolif-eration in leukemia relapse,and play a key role in the process.The existing and proliferation of Leukaemia stem cells are due to surface molecules,cellular control signal pathways,cell self-renewal signal pathways and bone marrow micro environment factors.Among these factors,the cell self-renewal signal pathways and its gene expression in maintaining leukaemia stem cell biology characteristics play a major role.