非典型恶性综合征1 例报告暨文献复习

目的:探讨恶性综合征的病因、发病机制、临床表现及治疗。方法:回顾性分析1例非典型恶性综合征患者1例,结合文献进行分析讨论。结果:患者因高龄、全身状况差、长期并联合应用多种抗精神病药物、合并应用多种其他药物而诱发,表现为肌张力增高,心率增快,血压增高,经过停用抗精神病药,给予甲磺酸溴隐亭片、盐酸金刚烷胺片及对症支持治疗,患者病情好转。结论:恶性综合征是抗精神病药物治疗的严重并发症,其临床表现可无发热等典型表现,且可出现各系统症状,可能首诊于多个科室,各科临床医师均应熟悉该病的临床表现,以便及时作出诊断,及时治疗,改善患者预后。

A Case Report of Atypical Neuroleptic Malignant Syndrome and Review of the Literature

Objective: To investigate the etiology,pathogenesis,clinical manifestations and treatment of neuroleptic malignant syndrome(NMS).Methods: All clinical data of one NMS were studied retrospectively.Results: The patient presented with altered levels of consciousness,increased muscular rigidity,tachycardia and hypertension,tremor,and elevation of serum creatine kinase(CK).Antipsychotic drugs was discontinued,and he received oral bromocriptine mesilate and amantadine,the patient was recovered quickly.Conclusion: NMS is a severe complication during treatment with antipsychotic drug.The manifestation can be atypical and various.The patient may came to other department beside neurology and psychiatry,so all the internal medicine doctors should be familiar with the disease.Then the NMS patient can be diagnosed and treated quickly and correctly.The prognosis will be better.