| 伏隔核微注射orexin-A 对大鼠摄食和活动的影响 |
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| 引用本文： | 张丽娜 冯彩华 柴薪 王丛丛 董海龙. 伏隔核微注射orexin-A 对大鼠摄食和活动的影响[J]. 现代生物医学进展, 2012, 12(9): 1621-1623 |
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| 作者姓名： | 张丽娜 冯彩华 柴薪 王丛丛 董海龙 |
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| 作者单位： | 1. 第四军医大学附属西京医院麻醉科 陕西西安710032
2. 第四军医大学口腔医院麻醉科 陕西西安710032 |
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| 基金项目： | 国家自然科学基金资助项目(30772075) |
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| 摘 要： | 目的:探讨伏隔核微注射orexin-A后,大鼠摄食和活动的变化。方法:采用SD大鼠(250-280g),用脑立体定位仪在伏隔核植入微量注射管。大鼠随机分组,分别微注射乳酸格林液(Ringer’s),orexin-A 100pmol和500pmol。观察微注射后大鼠0-1h,1-2h,2-4h摄食和0-30min,30-60min,60-90min,90-120min活动性变化。结果:Orexin-A微注射后,大鼠0-1h,1-2h摄食量增加;30-60min,60-90min,90-120min的活动性显著增加(P<0.05 vs对照组)。结论:伏隔核是orexin-A刺激大鼠增加摄食量,提高其活动性的作用点。
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| 关 键 词： | 伏隔核 orexin-A 摄食 |
The Effect of Orexin-A on Feeding and Locomotor Activity inthe Accumbens |
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| ZHANG Li-n,FENG Cai-hu,CHAI-Xin,WANG Cong-cong,DONG Hai-long. The Effect of Orexin-A on Feeding and Locomotor Activity inthe Accumbens[J]. Progress in Modern Biomedicine, 2012, 12(9): 1621-1623 |
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| Authors: | ZHANG Li-n FENG Cai-hu CHAI-Xin WANG Cong-cong DONG Hai-long |
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| Affiliation: | 1(1 Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,China;2 Department of Anesthesiology,Kouqiang Hospital,Fourth Military Medical University,Xi’an 710032,China) |
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| Abstract: | Objective:To investigate the effect of orexin-A on feeding and locomotor activity in the accumbens shell(Accsh).Methods: SD rats(250-280) were used and implanted a guide cannulae into the accumbens shell(AccSh) by stereotaxic instrument.Then rats were randomly divided into three group and microinjected Ringer’s solution,100 pmol and 500 pmol orexin-A respectively.The feeding were recorded in 0-1h,1-2h,2-4h and locomotor activity were recorded in 0-30 min,30-60min,60-90min,90-120min after micinjection.Results: Orexin-A augmented feeding in the 0-1 h and 1-2 h and stimulated locomotor activity in the 30-60 min,60-90 min,and 90-120 min post-infusion(P < 0.05 vs control group).Conclusion: AccSh is a site of orexin A modulation of feeding behavior and locomotor activity. |
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| Keywords: | Accumbens Orexin-A Feeding |
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