| 细胞因子与类风湿关节炎的研究进展 |
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| 引用本文： | 张军芳蒋飞霞张宜夏永祥. 细胞因子与类风湿关节炎的研究进展[J]. 现代生物医学进展, 2012, 12(4): 735-738 |
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| 作者姓名： | 张军芳蒋飞霞张宜夏永祥 |
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| 作者单位： | 南京医科大学附属南京第一医院医学检验科 江苏南京210006 |
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| 摘 要： | 类风湿关节炎(RA)是一种慢性、多系统的以关节的炎症损害为主要特点的自身免疫性疾病。其发病过程与多种细胞因子有关,包括TNF-α、IL-1、MMPS、IL-6、IL-17、IL-18等,这些细胞因子在RA的发病进程中起了很重要的作用,可作为治疗RA的新靶点。
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| 关 键 词： | 类风湿关节炎 白细胞介素 肿瘤坏死因子 基质金属蛋白酶 |
Progress of the Studies on Relationships between Cytokinesand Rheumatoid Arthritis |
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| ZHANG Jun-fang,JIANG Fei-xi,ZHANG Yi,XIA Yong-xiang. Progress of the Studies on Relationships between Cytokinesand Rheumatoid Arthritis[J]. Progress in Modern Biomedicine, 2012, 12(4): 735-738 |
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| Authors: | ZHANG Jun-fang JIANG Fei-xi ZHANG Yi XIA Yong-xiang |
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| Affiliation: | (Department of Clinical Laboratory,Nanjing First Hospital Affiliated to Nanjing Medical University,Province Jiangsu,Nanjing,210006) |
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| Abstract: | Rheumatoid arthritis(RA) is an autoimmune disease characterized by chronic inflammation leading to joint destruction with systemic involvement.The pathogenesis of rheumatoid arthritis are related to many cytokines,such as TNF-α,IL-1,MMPS,IL-6,IL-17,IL-18 and so on.It has been confirmed the cytokine-mediated immunity plays a crucial role in the pathoge-nesis of RA and anti-cytokine therapy has become novel target treatment for RA. |
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| Keywords: | Rheumatoid arthritis Interleukin Tumor necrosis factor Matrix metalloproteinases |
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