促排卵周期中未破裂黄素化卵泡综合征与性激素的关系探讨

目的:对未破裂黄素化卵泡综合征(LUFS)周期及正常排卵周期患者在不同时间性激素进行测定与比较,探讨LUFS的发生与性激素的关系。方法:对自然周期有排卵障碍的患者使用克罗米芬+HCG促排,分别在月经周期的第3天(C3)、第10天(C10)、卵泡成熟日(CM)(卵泡直径≥18mm)、尿LH阳性或注射HCG后48小时(CL)进行性激素测定,根据患者是否有排卵分为:正常排卵组(A组);未排卵出现LUFS组(B组)。选择同期自然周期正常排卵者为对照组(C组),同上法进行性激素测定。对A、B、C组患者不同时间的血清性激素进行比较。结果:1、FSH:在CM日A、B两组的促卵泡成熟激素(FSH)均低于C组(P<0.01)。2、LH:在C3、C10、CL日测定的A、B组LH值均高于C组(P<0.01),在CM日测定的A、B组LH值低于C组(P<0.01)。3、P:在CM日A、B两组的孕酮值低于C组(P<0.01);4、E2:在C3日测定的B组E2值低于C组(P<0.01),在CL日测定的B组E2值高于C组(P<0.01);5、PRL:在不同时间各组的PRL值均无显著性差异(P>0.05)。6、T:在不同时间各组的T值均无显著性差异(P>0.05)。结论:性激素在LUFS的发生中起重要作用,但以C3日E2值与LUFS的发生的关系最大,E2值低者易发生LUFS。

Analysis on the Relationship between Luteinized Unruptured FollicleSyndrome and Hormone in the Cycle of Ovulation Induction

Objective: This research discusses the relationship between the LUFS occurrence and hormone level of LUFS patients by comparing hormone levels during different periods in both LUFS cycle patients and normal ovulatory cycle patients.Methods: The infertile women with ovulatory dysfunction were treated by taking CC + HCG.The levels of the serum follicle stimulating hormone(FSH),Luteinizing hormone(LH),estradiol(E2),progesterone(P),prolactin(PRL),testoster(T) were measured respectively on the third day(C3),10th day(C10),follicle maturity day(CM),48 hours after urine LH+ or injection with HCG(CL).Ovulation were surveyed with transvaginal ultrasonography(TVS)at the same time.Depending on these results,here were two groups: Group A,ovulation after induced ovulation,and group B,LUFS after induced ovulation.Besides,normal ovulation in natural cycle as group C,and received the same detection.Results: 1.The level of FSH on CM day of group A and B obviously was lower than that of group C(P<0.01).2.The level of LH of group A and B was obviously higher than that of group C on C3 and C10 and CL day(P<0.01),but lower than that of group C on CM day(P<0.01).3.The level of P on CM day of group A and B was obviously lower than that of group C(P<0.01).4.The level of E2 in group B was obviously lower than that in group C on C3 day(P<0.01),but higher than that in group C on CL day(P<0.01).5.No difference of the PRL level or the T Level was found among all the groups at different time(P>0.05).Conclusion: Sex hormones play important roles in LUFS occurrence.Here the E2 value on C3 is the most important factor during these hormone level.Low E2 level easily causes LUFS.